Blenrep: how long were the pivotal tox studies?

“Monkeys were dosed in GLP-compliant repeat-dose general toxicology studies for 3 or 13 weeks with IV bolus doses of 0, 1, 3, or 10 mg/kg belantamab mafodotin, with 12-week recovery periods.”

“The 3-week and 13-week rat studies utilized weekly and every 3 weeks (q3w) dosing regimens, respectively. Monkeys were dosed in GLP-compliant repeat-dose general toxicology studies for 3 or 13 weeks with IV bolus doses of 0, 1, 3, or 10 mg/kg belantamab mafodotin, with 12-week recovery periods.”

“The 3-week and 13-week rat studies utilized weekly and every 3 weeks (q3w) dosing regimens, respectively. Monkeys were dosed in GLP-compliant repeat-dose general toxicology studies for 3 or 13 weeks with IV bolus doses of 0, 1, 3, or 10 mg/kg belantamab mafodotin, with 12-week recovery periods.”

“rats were dosed for 3 or 13 weeks with intravenous (IV) doses (10-minute infusion) of 0, 3, 10, or 30 mg/kg belantamab mafodotin”