Velsipity: which tox species, and why?

“Repeat-dose toxicity studies of up to six months duration in rats and nine months duration in dogs were conducted to support the chronic use of etrasimod in humans.”

“The overview shows that rats were exposed sufficiently to the metabolites M3 and M6 during toxicity testing.”

“No adverse effects were observed in rats or dogs at exposures up to 738- and 446-fold, respectively, the exposure at the MRHD (based on AUC comparison).”

“repeat-dose toxicology studies of up to six months duration in rats and nine months duration in dogs”

“a standard battery of developmental and reproductive toxicity studies in rats and rabbits”

“Bioassays were performed in Crl: CD1 (ICR) mice and Sprague Dawley rats.”

“In similar β-arrestin recruitment assays etrasimod was determined to be as well a potent full agonist on mouse, dog, and monkey S1P1 receptors with similar mean EC50 values, ranging from 3.65 to 8.70 nM (mean efficacy > 80% S1P), across species.”